Mast Cells& Allergy

More than 50+ million people in America experience allergy symptoms with Texans getting their fair share.  Sneezing, mucus, itchy eyes are common with asthma a possibility.  Eczema or Atopic Dermatitis are also an allergic response.  Histamine from food may contribute to additional symptoms as well.  While helping create the problem, the body does have systems that can help deal with them.  The objective is to identify the functionality of these and support them in a positive way.  The body produces enzymes HMT and DAO that metabolize histamine from allergens and food.

Here is a short outline of what is happening in the body with most allergies.

  • Antigens or allergens from pollen or food interact with immune cells. The B-cells may then react to the allergen and create IgE antibodies that attach to Mast Cells that line body surfaces.  When the allergens interact with the IgE, the Mast Cells can begin to breakdown or degranulate and release symptom causing histamine in the process.

Mast Cell Stabilization and Histamine Reduction

Here are naturally occurring molecules with successful research results that showed to stabilize mast cells and limit the amount of histamine released.

  • Quercetin in the EMIQ form stabilizes Mast Cells, inhibits histamine release and significantly reduced “itchy eye” allergy symptoms.
  • Nettle Leaf Extract reduced histamine release.
  • L-92 Sterilized Lactobacillus Acidophillus strain reduced allergy, atopic dermatitis and shifted the immune emphasis from allergy Th2 to Th1.
  • Flavonoid Luteolin stabilized Mast Cells and reduced immune activation.
  • Perilla Extract reduces activity in allergy forming Th2 antibody pathway, mast cells and longer lasting eosinophil allergy symptoms.
  • Vitamin C is an activating cofactor for histamine reducing enzyme HMT in the body.
  • Probiotic Strain BB536 increased short chain fat butyrate formation that supports Mast Cell stabilization and immune modulating TReg cells.

Food Histamine

Foods may contain histamine or cause the release of histamine resulting in both systemic and GI tract symptoms.  Foods that are fermented, cured meats or older meats all tend to contain higher levels of histamine.  There are probiotic strains that breakdown food histamine as well as DAO produced in the body or in supplemental form.

  • Strains Plantarum 299V, BB536, and Rhamnosus GG all supported Mast Cell stabilization and increased histamine breakdown from food.


References available upon request.  *These statements have not been evaluated by the Food and Drug Administration.  Research, nutritional information and products are not intended to diagnose, treat, cure or prevent any disease.  Consult your physician before initiating any new dietary or supplement program.