Benefits for Mitochondria, Muscle, & Immune Function
Urolithin A is a natural compound produced in the gut during the breakdown of specific antioxidants. However, only about 30-40% of people have the specific microbiome needed to produce it naturally.
Supplementation of urolithin A has been shown to enhance mitochondrial function, reduce inflammation, and improve muscle performance, making it a promising tool for healthy aging.
How It Works: Mitophagy
Urolithin A helps activate mitophagy, the essential cellular process that removes damaged mitochondria and replaces them with healthy ones. Because mitochondria generate the energy our cells need to function, this renewal process helps counteract age-related declines in both physical performance and metabolic health.
Muscle Strength and Endurance
Urolithin A supplementation increases mitochondrial proteins and abundance in human skeletal muscle, supporting improvements in strength, endurance, and exercise performance.
- A study found that adults aged 65–90 taking 1,000 mg daily for two months experienced 6–7× greater improvements in muscle endurance compared with placebo.
- In another randomized trial involving 88 overweight middle-aged adults, 500–1,000 mg per day for four months resulted in 9.8–12% increase in leg muscle strength, approximately 10% improvement in knee-flexion torque, and about 5% increase in hand-grip strength and aerobic capacity.
Immune System Support
Emerging research also suggests benefits for immune health. A placebo-controlled study found that adults aged 45–70 taking 1,000 mg daily for 28 days showed a 15% improvement in immune-cell energy metabolism and an increase in CD8 T cells, which help the body respond to new infections.
References: JAMA Network Open. 2022 Jan 4 Cell Reports. Medicine. 2022 May 17 Nature Aging. 2025 Oct 31 Calcified Tissue Int. 2023 Nov 5 Ageing Research Reviews. 2024 Sep
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
