Estrovera-Relief for Menopause Symptoms

Menopause is defined as the permanent end of menstruation. The average age for menopause is 51, but can occur anytime during the 40’s and 50’s. Perimenopause is the time before the very last menstrual cycle and can last as long as 10 years. During this time estrogen and progesterone levels are dropping. The drop in estrogen causes the well-known “menopausal” symptoms such as hot flashes and vaginal dryness. Some women choose hormone replacement therapy to find relief, but there can be risks.

ERr731® is a polyphenol extracted from Rheum rhaponticum  or Siberian rhubarb from Asia. This molecule has been recommended by doctors in Germany since 1993 for the relief of perimenopausal symptoms. It is now being studied here.

A 12-week randomized controlled trial found that ERr731® reduced symptoms by as much as 83%. The women were followed for 2 years and maintained the results

Symptoms that clinically improved included:

  • Hot flashes
  • Vaginal dryness
  • Sleep disturbances
  • Sexual problems
  • Negative mood
  • Urinary tract discomfort
  • Physical and mental exhaustion
  • Irritability


Estrovera®, developed by health professional Metagenics, is a supplement that contains ERr731®. In a 2020 survey, over 50% of women who used Estrovera®, reported that they saw relief from hot flashes and night sweats in 1- 4 weeks. Metagenics so believes in the research, that they offer a money-back guarantee on Estrovera®.


J Midlife Health. 2021,   Int J Mol Sci. 2021, Menopause 2006,


*These statements have not been evaluated by the Food and Drug Administration.  Research, nutritional information and products are not intended to diagnose, treat, cure or prevent any disease.  Consult your physician before initiating any new dietary or supplement program.